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Literature summary for 3.4.24.B5 extracted from
- The prognostic value of matrix metalloproteinase-7 and matrix metalloproteinase-15 in acute myeloid leukemia (2019), J. Cell. Biochem., 120, 10613-10624 .
Application
| Application | Comment | Organism |
|---|---|---|
| diagnostics | potential role of MMP15 in the prognosis of acute myeloid leukemia (AML). MMP7 and MMP15 expression is associated with various clinicopathological characteristics in AML, but MMP7 or MMP15 expression signature are not independent prognostic factors in AML as compared with risk stratifications | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene MMP15, quantitative expression analysis | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| extracellular matrix | - |
Homo sapiens | 31012 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | a zinc-dependent endopeptidase | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P51511 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | peripheral | Homo sapiens | - |
| bone marrow | - |
Homo sapiens | - |
| carcinoma cell | MMP15 is highly expressed in multiple cancers. MMP15 is highly expressed in esophageal carcinoma and lung carcinoma | Homo sapiens | - |
| esophageal cancer cell | - |
Homo sapiens | - |
| HL-60 cell | - |
Homo sapiens | - |
| lung cancer cell | - |
Homo sapiens | - |
| additional information | MMP15 is highly expressed both in bone marrow and peripheral blood in collected acute myeloid leukemia (AML) samples compared with healthy individuals | Homo sapiens | - |
| myeloid leukemia cell | MMP15 is overexpressed in acute myeloid leukemia (AML) patients | Homo sapiens | - |
| NB-4 cell | - |
Homo sapiens | - |
| THP-1 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MMP15 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | enzyme MMP15 mainly play roles in extracellular matrix disassembly | Homo sapiens |
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Release 2023.1 (January 2023)
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